In eight years with the national side, McDonough amassed 117 caps since her debut against England in 2001 under Riet Kuper.
Speaking on her decision, the Belfast Harlequins forward said “Unfortunately I am unable to give my full commitment to the build-up to the EuroHockey Nations Championship in Holland this August due to my forthcoming wedding, work and other personal commitments.
"There is a clear focus towards the Olympics in London in 2012 and as I am unable to commit to this campaign I feel it is time for me to retire.
"I would like to thank the National Coach Gene Muller; Gene has been an inspiring coach, I have learnt a lot from him and I am only sorry that my time playing under him was so short. I am confident that the team will be extremely successful under his direction. I would also like to thank our previous coach Riet Kuper for giving me the opportunity to play for Ireland."
Muller, in response to the decision, said “Jenny has been an asset to the national team over the past few years and I am sad to see her step down. She has always been a dedicated and professional international player.”
McDonough will continue playing for Belfast Harlequins.